So here's a weird one.
See, in using a computer mouse, I've always rested the heel of my hand on the desk (or a wrist-rest), keeping it stationary while I pushed the mouse around with the tips of my thumb and pinky, keeping the tips of the three other fingers on the buttons and scroll wheel.
Recently, I switched to a basic optical mouse, as I was tired of cat hairs interfering with the smooth operation of the mouse ball. The optical mouse had a much slimmer profile than the old mechanical mouse, and over the last few days my hand has been hurting more and more after using it. So today I went out to get a more ergonomic mouse. After comparing comfort, features and prices, I ended up with a Logitech MX 1000. And it's really comfortable to use (as long as you're right-handed) and has lots of interesting, conveniently placed (if you're right-handed) buttons.
But the way it's shaped, I find I have to put my entire hand on it if I want to keep my fingers on the main buttons and scroll wheel, otherwise I have to move my fingers a lot to click and scroll. Which means moving the whole hand, which I find quite a bit less precise than moving it with my fingers — and the three inner fingers are lying across the buttons, rather than just touching them with the tips, otherwise my thumb's in the wrong place to use the side button, and it becomes much less comfortable. So it makes me wonder if I've been mousing wrong in a highly unorthodox fashion all these years (well, at least since got rid of the GlidePoint), or if ergonomic mice are designed to be used in a different way than regular bar-of-soap mice.
So how do you use a mouse?